rs4369876
Variant in the SCN9A gene (Sodium Voltage-Gated Channel Alpha Subunit 9)
rs4369876 is a single nucleotide polymorphism (SNP) in the SCN9A gene, involved in voltage-gated sodium channel signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4369876 variant?
rs4369876 is a SNP (single nucleotide polymorphism) in the SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9) gene. It belongs to the Pain Sensory category and is part of the Pain & Sensory Processing biological cluster. SCN9A encodes Nav1.7, a voltage-gated sodium channel critical for pain signal transmission in peripheral sensory neurons.
Biological role and pathway
This variant sits within the SCN9A gene, which is involved in the voltage-gated sodium channel signaling pathway. Genes within the Pain & Sensory Processing cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4369876 and Long COVID / ME-CFS research
SCN9A variants affecting Nav1.7 function have been studied in relation to small fiber neuropathy and chronic pain in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SCN9A
rs4369876 is one of 2 known variants in the SCN9A gene. To understand the full biological context of this variant, explore the parent gene page.
View SCN9A gene page →Conditions studied in relation to rs4369876
Research into SCN9A variants including rs4369876 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SCN9A and the rs4369876 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SCN9A gene
The following variants in SCN9A are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4369876 variant in the SCN9A gene?
rs4369876 is a single nucleotide polymorphism (SNP) located in the SCN9A (Sodium Voltage-Gated Channel Alpha Subunit 9) gene, which is involved in voltage-gated sodium channel signaling. SCN9A encodes Nav1.7, a voltage-gated sodium channel critical for pain signal transmission in peripheral sensory neurons.
How may the rs4369876 variant relate to Long COVID or ME/CFS?
SCN9A variants affecting Nav1.7 function have been studied in relation to small fiber neuropathy and chronic pain in Long COVID.
Can a consumer DNA test detect the rs4369876 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4369876 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SCN9A and its variants. This is not an exhaustive literature review.
- [1]PMID: 32272069
- [2]Nature Genetics
- [3]Journal of Clinical Investigation