rs11214775

What is the rs11214775 variant?

rs11214775 is a SNP (single nucleotide polymorphism) in the SDHA (Succinate Dehydrogenase Complex Flavoprotein Subunit A) gene. It belongs to the Mitochondrial category and is part of the Mitochondrial Energy Production & PEM biological cluster. SDHA encodes the flavoprotein subunit of succinate dehydrogenase (Complex II), linking the TCA cycle to the electron transport chain.

Biological role and pathway

This variant sits within the SDHA gene, which is involved in the TCA cycle and Complex II pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: SDHA

rs11214775 is one of 1 known variant in the SDHA gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs11214775

Research into SDHA variants including rs11214775 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SDHA and the rs11214775 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the SDHA gene

The following variants in SDHA are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions