rs11214775
Variant in the SDHB gene (Succinate Dehydrogenase Complex Iron Sulfur Subunit B)
rs11214775 is a single nucleotide polymorphism (SNP) in the SDHB gene, involved in TCA cycle and Complex II. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs11214775 variant?
rs11214775 is a SNP (single nucleotide polymorphism) in the SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B) gene. It belongs to the Mitochondrial category and is part of the Mitochondrial Energy Production & PEM biological cluster. SDHB encodes the iron-sulfur subunit of succinate dehydrogenase, essential for electron transfer between succinate and ubiquinone.
Biological role and pathway
This variant sits within the SDHB gene, which is involved in the TCA cycle and Complex II pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs11214775 and Long COVID / ME-CFS research
SDHB dysfunction disrupts the TCA cycle-electron transport chain link; variants may contribute to metabolic inefficiency in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SDHB
rs11214775 is one of 1 known variant in the SDHB gene. To understand the full biological context of this variant, explore the parent gene page.
View SDHB gene page →Conditions studied in relation to rs11214775
Research into SDHB variants including rs11214775 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SDHB and the rs11214775 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs11214775 variant in the SDHB gene?
rs11214775 is a single nucleotide polymorphism (SNP) located in the SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B) gene, which is involved in TCA cycle and Complex II. SDHB encodes the iron-sulfur subunit of succinate dehydrogenase, essential for electron transfer between succinate and ubiquinone.
How may the rs11214775 variant relate to Long COVID or ME/CFS?
SDHB dysfunction disrupts the TCA cycle-electron transport chain link; variants may contribute to metabolic inefficiency in Long COVID.
Can a consumer DNA test detect the rs11214775 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs11214775 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SDHB and its variants. This is not an exhaustive literature review.
- [1]PMID: 32735956
- [2]Nature Genetics
- [3]Journal of Clinical Investigation