rs6136
Variant in the SELP gene (Selectin P)
rs6136 is a single nucleotide polymorphism (SNP) in the SELP gene, involved in platelet-leukocyte interactions. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs6136 variant?
rs6136 is a SNP (single nucleotide polymorphism) in the SELP (Selectin P) gene. It belongs to the Cell Adhesion category and is part of the Coagulation & Vascular biological cluster. P-selectin (CD62P) is stored in platelet alpha-granules and endothelial Weibel-Palade bodies. Rapid surface expression upon activation mediates platelet-leukocyte-endothelium interactions initiating inflammatory thrombosis.
Biological role and pathway
This variant sits within the SELP gene, which is involved in the platelet-leukocyte interactions pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs6136 and Long COVID / ME-CFS research
P-selectin is elevated in COVID-19-associated coagulopathy and platelet hyperactivation. Elevated soluble P-selectin is a biomarker of ongoing platelet activation in Long COVID microthrombi formation. SELP variants affecting platelet reactivity may influence thrombotic risk.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SELP
rs6136 is one of 3 known variants in the SELP gene. To understand the full biological context of this variant, explore the parent gene page.
View SELP gene page →Conditions studied in relation to rs6136
Research into SELP variants including rs6136 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SELP and the rs6136 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SELP gene
The following variants in SELP are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs6136 variant in the SELP gene?
rs6136 is a single nucleotide polymorphism (SNP) located in the SELP (Selectin P) gene, which is involved in platelet-leukocyte interactions. P-selectin (CD62P) is stored in platelet alpha-granules and endothelial Weibel-Palade bodies. Rapid surface expression upon activation mediates platelet-leukocyte-endothelium interactions initiating inflammatory thrombosis.
How may the rs6136 variant relate to Long COVID or ME/CFS?
P-selectin is elevated in COVID-19-associated coagulopathy and platelet hyperactivation. Elevated soluble P-selectin is a biomarker of ongoing platelet activation in Long COVID microthrombi formation. SELP variants affecting platelet reactivity may influence thrombotic risk.
Can a consumer DNA test detect the rs6136 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs6136 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for SELP and its variants. This is not an exhaustive literature review.
- [1]PMID: 33203849
- [2]Blood
- [3]Nature Medicine