rs1799889

What is the rs1799889 variant?

rs1799889 is a SNP (single nucleotide polymorphism) in the SERPINE1 (Serpin Family E Member 1 (PAI-1)) gene. It belongs to the Coagulation category and is part of the Coagulation & Microcirculation biological cluster. SERPINE1 encodes plasminogen activator inhibitor-1 (PAI-1), the primary inhibitor of fibrinolysis, promoting clot persistence.

Biological role and pathway

This variant sits within the SERPINE1 gene, which is involved in the fibrinolysis regulation pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: SERPINE1

rs1799889 is one of 1 known variant in the SERPINE1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1799889

Research into SERPINE1 variants including rs1799889 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SERPINE1 and the rs1799889 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions