rs2232701
Variant in the SERPINF2 gene (Serpin Family F Member 2)
rs2232701 is a single nucleotide polymorphism (SNP) in the SERPINF2 gene, involved in fibrinolysis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2232701 variant?
rs2232701 is a SNP (single nucleotide polymorphism) in the SERPINF2 (Serpin Family F Member 2) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. SERPINF2 (α2-antiplasmin) is the primary plasmin inhibitor in plasma, rapidly inactivating free plasmin to regulate fibrinolysis. Elevated α2-antiplasmin causes impaired fibrinolysis and hypofibrinolysis.
Biological role and pathway
This variant sits within the SERPINF2 gene, which is involved in the fibrinolysis pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2232701 and Long COVID / ME-CFS research
α2-antiplasmin-plasmin balance determines net fibrinolytic activity. Elevated SERPINF2 or variants increasing α2-antiplasmin activity may contribute to the hypofibrinolysis and resistance to fibrin dissolution documented in Long COVID microthrombi.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SERPINF2
rs2232701 is one of 2 known variants in the SERPINF2 gene. To understand the full biological context of this variant, explore the parent gene page.
View SERPINF2 gene page →Conditions studied in relation to rs2232701
Research into SERPINF2 variants including rs2232701 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SERPINF2 and the rs2232701 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SERPINF2 gene
The following variants in SERPINF2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2232701 variant in the SERPINF2 gene?
rs2232701 is a single nucleotide polymorphism (SNP) located in the SERPINF2 (Serpin Family F Member 2) gene, which is involved in fibrinolysis. SERPINF2 (α2-antiplasmin) is the primary plasmin inhibitor in plasma, rapidly inactivating free plasmin to regulate fibrinolysis. Elevated α2-antiplasmin causes impaired fibrinolysis and hypofibrinolysis.
How may the rs2232701 variant relate to Long COVID or ME/CFS?
α2-antiplasmin-plasmin balance determines net fibrinolytic activity. Elevated SERPINF2 or variants increasing α2-antiplasmin activity may contribute to the hypofibrinolysis and resistance to fibrin dissolution documented in Long COVID microthrombi.
Can a consumer DNA test detect the rs2232701 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2232701 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for SERPINF2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33483441
- [2]Blood
- [3]Thrombosis and Haemostasis