rs721917
Variant in the SFTPD gene (Surfactant Protein D)
rs721917 is a single nucleotide polymorphism (SNP) in the SFTPD gene, involved in pulmonary innate immunity. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs721917 variant?
rs721917 is a SNP (single nucleotide polymorphism) in the SFTPD (Surfactant Protein D) gene. It belongs to the Immune Signaling category and is part of the Respiratory & Lung Function biological cluster. SFTPD encodes surfactant protein D, a collectin that opsonizes pathogens and modulates pulmonary innate immune responses.
Biological role and pathway
This variant sits within the SFTPD gene, which is involved in the pulmonary innate immunity pathway. Genes within the Respiratory & Lung Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs721917 and Long COVID / ME-CFS research
Surfactant protein D recognizes SARS-CoV-2 and modulates pulmonary inflammation; variants may affect COVID-19 severity and Long COVID pulmonary immune responses.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SFTPD
rs721917 is one of 2 known variants in the SFTPD gene. To understand the full biological context of this variant, explore the parent gene page.
View SFTPD gene page →Conditions studied in relation to rs721917
Research into SFTPD variants including rs721917 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SFTPD and the rs721917 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SFTPD gene
The following variants in SFTPD are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs721917 variant in the SFTPD gene?
rs721917 is a single nucleotide polymorphism (SNP) located in the SFTPD (Surfactant Protein D) gene, which is involved in pulmonary innate immunity. SFTPD encodes surfactant protein D, a collectin that opsonizes pathogens and modulates pulmonary innate immune responses.
How may the rs721917 variant relate to Long COVID or ME/CFS?
Surfactant protein D recognizes SARS-CoV-2 and modulates pulmonary inflammation; variants may affect COVID-19 severity and Long COVID pulmonary immune responses.
Can a consumer DNA test detect the rs721917 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs721917 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SFTPD and its variants. This is not an exhaustive literature review.
- [1]PMID: 33141942
- [2]Nature Genetics
- [3]American Journal of Respiratory Cell and Molecular Biology