rs61768452

What is the rs61768452 variant?

rs61768452 is a SNP (single nucleotide polymorphism) in the INPP5D (Inositol Polyphosphate-5-Phosphatase D (SHIP1)) gene. It belongs to the Signaling category and is part of the Immune System & Inflammation biological cluster. INPP5D encodes SHIP1, a phosphoinositide 5-phosphatase that negatively regulates PI3K signaling in B cells, macrophages, and mast cells.

Biological role and pathway

This variant sits within the INPP5D gene, which is involved in the PI3K inhibition / B cell and myeloid regulation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: INPP5D

rs61768452 is one of 2 known variants in the INPP5D gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs61768452

Research into INPP5D variants including rs61768452 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include INPP5D and the rs61768452 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the INPP5D gene

The following variants in INPP5D are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions