rs7982

What is the rs7982 variant?

rs7982 is a SNP (single nucleotide polymorphism) in the INPPL1 (Inositol Polyphosphate Phosphatase Like 1 (SHIP2)) gene. It belongs to the Signaling category and is part of the Metabolic Regulation biological cluster. INPPL1 encodes SHIP2, which dephosphorylates PIP3 and negatively regulates insulin signaling.

Biological role and pathway

This variant sits within the INPPL1 gene, which is involved in the PI3K inhibition / insulin signaling pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: INPPL1

rs7982 is one of 1 known variant in the INPPL1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs7982

Research into INPPL1 variants including rs7982 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include INPPL1 and the rs7982 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions