rs7595407
Variant in the SIRPA gene (Signal Regulatory Protein Alpha (SIRPalpha/CD172a))
rs7595407 is a single nucleotide polymorphism (SNP) in the SIRPA gene, involved in CD47 inhibitory signaling / phagocytosis regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs7595407 variant?
rs7595407 is a SNP (single nucleotide polymorphism) in the SIRPA (Signal Regulatory Protein Alpha (SIRPalpha/CD172a)) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. SIRPA encodes SIRPα, the receptor for CD47 on macrophages and dendritic cells that transmits inhibitory 'don't eat me' signals.
Biological role and pathway
This variant sits within the SIRPA gene, which is involved in the CD47 inhibitory signaling / phagocytosis regulation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs7595407 and Long COVID / ME-CFS research
SIRPA variants affect macrophage phagocytosis threshold; common polymorphisms in SIRPA influence macrophage phagocytic capacity relevant to clearance of SARS-CoV-2-infected cells in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SIRPA
rs7595407 is one of 1 known variant in the SIRPA gene. To understand the full biological context of this variant, explore the parent gene page.
View SIRPA gene page →Conditions studied in relation to rs7595407
Research into SIRPA variants including rs7595407 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SIRPA and the rs7595407 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs7595407 variant in the SIRPA gene?
rs7595407 is a single nucleotide polymorphism (SNP) located in the SIRPA (Signal Regulatory Protein Alpha (SIRPalpha/CD172a)) gene, which is involved in CD47 inhibitory signaling / phagocytosis regulation. SIRPA encodes SIRPα, the receptor for CD47 on macrophages and dendritic cells that transmits inhibitory 'don't eat me' signals.
How may the rs7595407 variant relate to Long COVID or ME/CFS?
SIRPA variants affect macrophage phagocytosis threshold; common polymorphisms in SIRPA influence macrophage phagocytic capacity relevant to clearance of SARS-CoV-2-infected cells in Long COVID.
Can a consumer DNA test detect the rs7595407 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs7595407 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SIRPA and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]Cell