rs12778366

What is the rs12778366 variant?

rs12778366 is a SNP (single nucleotide polymorphism) in the SIRT1 (Sirtuin 1) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. SIRT1 encodes the nuclear sirtuin that deacetylates histones and transcription factors (p53, FOXO, NF-kB) to regulate gene expression in response to NAD+ and caloric restriction.

Biological role and pathway

This variant sits within the SIRT1 gene, which is involved in the NAD+-dependent deacetylase / energy sensing / aging pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: SIRT1

rs12778366 is one of 3 known variants in the SIRT1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs12778366

Research into SIRT1 variants including rs12778366 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SIRT1 and the rs12778366 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the SIRT1 gene

The following variants in SIRT1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions