rs1051266
Variant in the SLC19A1 gene (Solute Carrier Family 19 Member 1 (Reduced Folate Carrier))
rs1051266 is a single nucleotide polymorphism (SNP) in the SLC19A1 gene, involved in folate transport. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1051266 variant?
rs1051266 is a SNP (single nucleotide polymorphism) in the SLC19A1 (Solute Carrier Family 19 Member 1 (Reduced Folate Carrier)) gene. It belongs to the Vitamin Metabolism category and is part of the Vitamin & Nutrient Metabolism biological cluster. SLC19A1 encodes the reduced folate carrier, the primary uptake mechanism for folate and methotrexate in most tissues.
Biological role and pathway
This variant sits within the SLC19A1 gene, which is involved in the folate transport pathway. Genes within the Vitamin & Nutrient Metabolism cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1051266 and Long COVID / ME-CFS research
SLC19A1 variants affecting cellular folate uptake may limit methylation cycle capacity relevant to Long COVID neurological and metabolic features.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SLC19A1
rs1051266 is one of 1 known variant in the SLC19A1 gene. To understand the full biological context of this variant, explore the parent gene page.
View SLC19A1 gene page →Conditions studied in relation to rs1051266
Research into SLC19A1 variants including rs1051266 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SLC19A1 and the rs1051266 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs1051266 variant in the SLC19A1 gene?
rs1051266 is a single nucleotide polymorphism (SNP) located in the SLC19A1 (Solute Carrier Family 19 Member 1 (Reduced Folate Carrier)) gene, which is involved in folate transport. SLC19A1 encodes the reduced folate carrier, the primary uptake mechanism for folate and methotrexate in most tissues.
How may the rs1051266 variant relate to Long COVID or ME/CFS?
SLC19A1 variants affecting cellular folate uptake may limit methylation cycle capacity relevant to Long COVID neurological and metabolic features.
Can a consumer DNA test detect the rs1051266 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1051266 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SLC19A1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 9694677
- [2]Nature Genetics
- [3]Journal of Clinical Investigation