rs1867351

What is the rs1867351 variant?

rs1867351 is a SNP (single nucleotide polymorphism) in the SLC22A1 (Solute Carrier Family 22 Member 1 (OCT1)) gene. It belongs to the Pharmacogenomics category and is part of the Detox & Medication Sensitivity biological cluster. SLC22A1 encodes organic cation transporter 1 (OCT1), expressed in the liver, which mediates hepatic uptake of metformin and other organic cations.

Biological role and pathway

This variant sits within the SLC22A1 gene, which is involved in the organic cation transport / drug metabolism pathway. Genes within the Detox & Medication Sensitivity cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: SLC22A1

rs1867351 is one of 2 known variants in the SLC22A1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1867351

Research into SLC22A1 variants including rs1867351 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SLC22A1 and the rs1867351 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the SLC22A1 gene

The following variants in SLC22A1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions