rs9952085
Variant in the SLC25A37 gene (Solute Carrier Family 25 Member 37 (Mitoferrin-1))
rs9952085 is a single nucleotide polymorphism (SNP) in the SLC25A37 gene, involved in mitochondrial iron import. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs9952085 variant?
rs9952085 is a SNP (single nucleotide polymorphism) in the SLC25A37 (Solute Carrier Family 25 Member 37 (Mitoferrin-1)) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. SLC25A37 encodes mitoferrin-1, the mitochondrial inner membrane iron transporter essential for heme and iron-sulfur cluster biosynthesis in erythroid cells.
Biological role and pathway
This variant sits within the SLC25A37 gene, which is involved in the mitochondrial iron import pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs9952085 and Long COVID / ME-CFS research
Mitochondrial iron import for heme synthesis is critical for erythropoiesis; variants may affect red blood cell production and hemoglobin synthesis impaired in Long COVID anemia.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SLC25A37
rs9952085 is one of 1 known variant in the SLC25A37 gene. To understand the full biological context of this variant, explore the parent gene page.
View SLC25A37 gene page →Conditions studied in relation to rs9952085
Research into SLC25A37 variants including rs9952085 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SLC25A37 and the rs9952085 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs9952085 variant in the SLC25A37 gene?
rs9952085 is a single nucleotide polymorphism (SNP) located in the SLC25A37 (Solute Carrier Family 25 Member 37 (Mitoferrin-1)) gene, which is involved in mitochondrial iron import. SLC25A37 encodes mitoferrin-1, the mitochondrial inner membrane iron transporter essential for heme and iron-sulfur cluster biosynthesis in erythroid cells.
How may the rs9952085 variant relate to Long COVID or ME/CFS?
Mitochondrial iron import for heme synthesis is critical for erythropoiesis; variants may affect red blood cell production and hemoglobin synthesis impaired in Long COVID anemia.
Can a consumer DNA test detect the rs9952085 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs9952085 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SLC25A37 and its variants. This is not an exhaustive literature review.
- [1]PMID: 34316049
- [2]Nature Genetics
- [3]Blood