rs5435

What is the rs5435 variant?

rs5435 is a SNP (single nucleotide polymorphism) in the SLC2A4 (Solute Carrier Family 2 Member 4 (GLUT4)) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. SLC2A4 encodes GLUT4, the insulin-regulated glucose transporter responsible for glucose uptake in muscle and adipose tissue.

Biological role and pathway

This variant sits within the SLC2A4 gene, which is involved in the insulin-stimulated glucose uptake pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: SLC2A4

rs5435 is one of 1 known variant in the SLC2A4 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs5435

Research into SLC2A4 variants including rs5435 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SLC2A4 and the rs5435 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions