rs9934336

What is the rs9934336 variant?

rs9934336 is a SNP (single nucleotide polymorphism) in the SLC5A2 (Solute Carrier Family 5 Member 2 (SGLT2)) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. SLC5A2 encodes SGLT2, the primary renal glucose reabsorber in the proximal tubule and the target of SGLT2 inhibitor drugs.

Biological role and pathway

This variant sits within the SLC5A2 gene, which is involved in the renal glucose reabsorption pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: SLC5A2

rs9934336 is one of 1 known variant in the SLC5A2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs9934336

Research into SLC5A2 variants including rs9934336 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SLC5A2 and the rs9934336 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions