rs1013940
Variant in the SLC5A7 gene (Solute Carrier Family 5 Member 7 (High-Affinity Choline Transporter))
rs1013940 is a single nucleotide polymorphism (SNP) in the SLC5A7 gene, involved in choline uptake for ACh synthesis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1013940 variant?
rs1013940 is a SNP (single nucleotide polymorphism) in the SLC5A7 (Solute Carrier Family 5 Member 7 (High-Affinity Choline Transporter)) gene. It belongs to the Neurotransmitter category and is part of the Autonomic Nervous System biological cluster. SLC5A7 encodes the high-affinity choline transporter (CHT1), which limits ACh synthesis by controlling choline uptake into cholinergic neurons.
Biological role and pathway
This variant sits within the SLC5A7 gene, which is involved in the choline uptake for ACh synthesis pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1013940 and Long COVID / ME-CFS research
CHT1-mediated choline uptake limits ACh synthesis; variants may affect cholinergic neurotransmission and the vagal anti-inflammatory reflex in Long COVID autonomic dysfunction.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SLC5A7
rs1013940 is one of 1 known variant in the SLC5A7 gene. To understand the full biological context of this variant, explore the parent gene page.
View SLC5A7 gene page →Conditions studied in relation to rs1013940
Research into SLC5A7 variants including rs1013940 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SLC5A7 and the rs1013940 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs1013940 variant in the SLC5A7 gene?
rs1013940 is a single nucleotide polymorphism (SNP) located in the SLC5A7 (Solute Carrier Family 5 Member 7 (High-Affinity Choline Transporter)) gene, which is involved in choline uptake for ACh synthesis. SLC5A7 encodes the high-affinity choline transporter (CHT1), which limits ACh synthesis by controlling choline uptake into cholinergic neurons.
How may the rs1013940 variant relate to Long COVID or ME/CFS?
CHT1-mediated choline uptake limits ACh synthesis; variants may affect cholinergic neurotransmission and the vagal anti-inflammatory reflex in Long COVID autonomic dysfunction.
Can a consumer DNA test detect the rs1013940 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1013940 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SLC5A7 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Journal of Neuroscience