rs36019
Variant in the SLC6A2 gene (Solute Carrier Family 6 Member 2 (Norepinephrine Transporter))
rs36019 is a single nucleotide polymorphism (SNP) in the SLC6A2 gene, involved in norepinephrine reuptake / sympathetic nervous system. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs36019 variant?
rs36019 is a SNP (single nucleotide polymorphism) in the SLC6A2 (Solute Carrier Family 6 Member 2 (Norepinephrine Transporter)) gene. It belongs to the Neurotransmitter category and is part of the Autonomic Nervous System biological cluster. SLC6A2 encodes the norepinephrine transporter (NET), which recycles norepinephrine at sympathetic synapses and adrenal chromaffin cells.
Biological role and pathway
This variant sits within the SLC6A2 gene, which is involved in the norepinephrine reuptake / sympathetic nervous system pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs36019 and Long COVID / ME-CFS research
NET dysfunction in cardiac and sympathetic neurons impairs norepinephrine reuptake; the SLC6A2 Ala457Pro variant is associated with orthostatic intolerance, a key mechanism in Long COVID POTS.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SLC6A2
rs36019 is one of 2 known variants in the SLC6A2 gene. To understand the full biological context of this variant, explore the parent gene page.
View SLC6A2 gene page →Conditions studied in relation to rs36019
Research into SLC6A2 variants including rs36019 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SLC6A2 and the rs36019 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SLC6A2 gene
The following variants in SLC6A2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs36019 variant in the SLC6A2 gene?
rs36019 is a single nucleotide polymorphism (SNP) located in the SLC6A2 (Solute Carrier Family 6 Member 2 (Norepinephrine Transporter)) gene, which is involved in norepinephrine reuptake / sympathetic nervous system. SLC6A2 encodes the norepinephrine transporter (NET), which recycles norepinephrine at sympathetic synapses and adrenal chromaffin cells.
How may the rs36019 variant relate to Long COVID or ME/CFS?
NET dysfunction in cardiac and sympathetic neurons impairs norepinephrine reuptake; the SLC6A2 Ala457Pro variant is associated with orthostatic intolerance, a key mechanism in Long COVID POTS.
Can a consumer DNA test detect the rs36019 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Related articles
- Long COVID Dysautonomia: What Your Genes May Reveal
Explore how genes in the autonomic nervous system may relate to Long COVID dysautonomia, including POTS, heart rate changes and orthostatic intolerance.
- Long COVID POTS: Symptoms, Testing and Genetics
Learn how Long COVID POTS affects heart rate, how standing and tilt table tests assess it, and which genes research is exploring.
Find out if you carry the rs36019 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for SLC6A2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32966261
- [2]Nature Genetics
- [3]Circulation