rs2652511
Variant in the SLC6A3 gene (Solute Carrier Family 6 Member 3 (Dopamine Transporter))
rs2652511 is a single nucleotide polymorphism (SNP) in the SLC6A3 gene, involved in dopamine reuptake. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2652511 variant?
rs2652511 is a SNP (single nucleotide polymorphism) in the SLC6A3 (Solute Carrier Family 6 Member 3 (Dopamine Transporter)) gene. It belongs to the Neurotransmitter category and is part of the Neurological & Cognitive Function biological cluster. SLC6A3 encodes the dopamine transporter (DAT), which removes dopamine from synaptic clefts and is essential for dopaminergic signal termination.
Biological role and pathway
This variant sits within the SLC6A3 gene, which is involved in the dopamine reuptake pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2652511 and Long COVID / ME-CFS research
DAT variants affecting dopamine clearance may influence dopaminergic dysfunction and cognitive fatigue in Long COVID brain fog.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SLC6A3
rs2652511 is one of 2 known variants in the SLC6A3 gene. To understand the full biological context of this variant, explore the parent gene page.
View SLC6A3 gene page →Conditions studied in relation to rs2652511
Research into SLC6A3 variants including rs2652511 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SLC6A3 and the rs2652511 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SLC6A3 gene
The following variants in SLC6A3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2652511 variant in the SLC6A3 gene?
rs2652511 is a single nucleotide polymorphism (SNP) located in the SLC6A3 (Solute Carrier Family 6 Member 3 (Dopamine Transporter)) gene, which is involved in dopamine reuptake. SLC6A3 encodes the dopamine transporter (DAT), which removes dopamine from synaptic clefts and is essential for dopaminergic signal termination.
How may the rs2652511 variant relate to Long COVID or ME/CFS?
DAT variants affecting dopamine clearance may influence dopaminergic dysfunction and cognitive fatigue in Long COVID brain fog.
Can a consumer DNA test detect the rs2652511 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2652511 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SLC6A3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Journal of Clinical Investigation