rs2306283
Variant in the SLCO1B1 gene (Solute Carrier Organic Anion Transporter Family Member 1B1)
rs2306283 is a single nucleotide polymorphism (SNP) in the SLCO1B1 gene, involved in drug transport. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2306283 variant?
rs2306283 is a SNP (single nucleotide polymorphism) in the SLCO1B1 (Solute Carrier Organic Anion Transporter Family Member 1B1) gene. It belongs to the Metabolism category and is part of the Pharmacogenomics biological cluster. SLCO1B1 (OATP1B1) is a hepatic uptake transporter for statins, bilirubin, bile acids, and many drugs. The rs4149056 variant significantly reduces statin transport, causing statin-induced myopathy.
Biological role and pathway
This variant sits within the SLCO1B1 gene, which is involved in the drug transport pathway. Genes within the Pharmacogenomics cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2306283 and Long COVID / ME-CFS research
Statins are being investigated for Long COVID treatment. SLCO1B1 rs4149056 dramatically increases statin plasma levels and myopathy risk. This pharmacogenomic variant is critical for personalizing statin-based therapies in Long COVID management.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SLCO1B1
rs2306283 is one of 3 known variants in the SLCO1B1 gene. To understand the full biological context of this variant, explore the parent gene page.
View SLCO1B1 gene page →Conditions studied in relation to rs2306283
Research into SLCO1B1 variants including rs2306283 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SLCO1B1 and the rs2306283 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SLCO1B1 gene
The following variants in SLCO1B1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2306283 variant in the SLCO1B1 gene?
rs2306283 is a single nucleotide polymorphism (SNP) located in the SLCO1B1 (Solute Carrier Organic Anion Transporter Family Member 1B1) gene, which is involved in drug transport. SLCO1B1 (OATP1B1) is a hepatic uptake transporter for statins, bilirubin, bile acids, and many drugs. The rs4149056 variant significantly reduces statin transport, causing statin-induced myopathy.
How may the rs2306283 variant relate to Long COVID or ME/CFS?
Statins are being investigated for Long COVID treatment. SLCO1B1 rs4149056 dramatically increases statin plasma levels and myopathy risk. This pharmacogenomic variant is critical for personalizing statin-based therapies in Long COVID management.
Can a consumer DNA test detect the rs2306283 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2306283 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for SLCO1B1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 25948572
- [2]Clinical Pharmacology & Therapeutics
- [3]NEJM