rs2796821

What is the rs2796821 variant?

rs2796821 is a SNP (single nucleotide polymorphism) in the SMAD2 (SMAD Family Member 2) gene. It belongs to the Signaling category and is part of the Cellular Signaling biological cluster. SMAD2 is an intracellular mediator of TGF-beta receptor signals, transducing them to the nucleus to regulate gene expression.

Biological role and pathway

This variant sits within the SMAD2 gene, which is involved in the TGF-beta receptor signaling pathway. Genes within the Cellular Signaling cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: SMAD2

rs2796821 is one of 1 known variant in the SMAD2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2796821

Research into SMAD2 variants including rs2796821 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SMAD2 and the rs2796821 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions