rs11616188
Variant in the SMAD3 gene (SMAD Family Member 3)
rs11616188 is a single nucleotide polymorphism (SNP) in the SMAD3 gene, involved in TGF-beta / SMAD signal transduction. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs11616188 variant?
rs11616188 is a SNP (single nucleotide polymorphism) in the SMAD3 (SMAD Family Member 3) gene. It belongs to the Signaling category and is part of the Coagulation & Microcirculation biological cluster. SMAD3 encodes the intracellular mediator of TGF-beta signaling that directly activates fibrotic gene expression.
Biological role and pathway
This variant sits within the SMAD3 gene, which is involved in the TGF-beta / SMAD signal transduction pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs11616188 and Long COVID / ME-CFS research
SMAD3-driven TGF-beta transcription is a key driver of lung fibrosis; variants may affect fibrotic remodeling in COVID-19 and Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SMAD3
rs11616188 is one of 2 known variants in the SMAD3 gene. To understand the full biological context of this variant, explore the parent gene page.
View SMAD3 gene page →Conditions studied in relation to rs11616188
Research into SMAD3 variants including rs11616188 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SMAD3 and the rs11616188 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SMAD3 gene
The following variants in SMAD3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs11616188 variant in the SMAD3 gene?
rs11616188 is a single nucleotide polymorphism (SNP) located in the SMAD3 (SMAD Family Member 3) gene, which is involved in TGF-beta / SMAD signal transduction. SMAD3 encodes the intracellular mediator of TGF-beta signaling that directly activates fibrotic gene expression.
How may the rs11616188 variant relate to Long COVID or ME/CFS?
SMAD3-driven TGF-beta transcription is a key driver of lung fibrosis; variants may affect fibrotic remodeling in COVID-19 and Long COVID.
Can a consumer DNA test detect the rs11616188 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs11616188 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SMAD3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33141942
- [2]Nature Genetics
- [3]Cell