rs2337104

What is the rs2337104 variant?

rs2337104 is a SNP (single nucleotide polymorphism) in the SMAD7 (SMAD Family Member 7) gene. It belongs to the Signaling category and is part of the Cellular Signaling biological cluster. SMAD7 is an inhibitory SMAD that negatively regulates TGF-beta and BMP signaling, acting as a feedback inhibitor.

Biological role and pathway

This variant sits within the SMAD7 gene, which is involved in the TGF-beta signaling inhibition pathway. Genes within the Cellular Signaling cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: SMAD7

rs2337104 is one of 1 known variant in the SMAD7 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2337104

Research into SMAD7 variants including rs2337104 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SMAD7 and the rs2337104 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions