rs4648299
Variant in the SNAI1 gene (Snail Family Transcriptional Repressor 1)
rs4648299 is a single nucleotide polymorphism (SNP) in the SNAI1 gene, involved in epithelial-mesenchymal transition / fibrosis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4648299 variant?
rs4648299 is a SNP (single nucleotide polymorphism) in the SNAI1 (Snail Family Transcriptional Repressor 1) gene. It belongs to the Signaling category and is part of the Coagulation & Microcirculation biological cluster. SNAI1 encodes the Snail transcription factor that drives epithelial-mesenchymal transition (EMT) by repressing E-cadherin and inducing mesenchymal markers.
Biological role and pathway
This variant sits within the SNAI1 gene, which is involved in the epithelial-mesenchymal transition / fibrosis pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4648299 and Long COVID / ME-CFS research
SNAI1-driven EMT is a key mechanism of post-injury fibrosis; SARS-CoV-2 infection induces EMT in lung epithelial cells, with SNAI1 variants potentially affecting the degree of fibrotic EMT in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SNAI1
rs4648299 is one of 1 known variant in the SNAI1 gene. To understand the full biological context of this variant, explore the parent gene page.
View SNAI1 gene page →Conditions studied in relation to rs4648299
Research into SNAI1 variants including rs4648299 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SNAI1 and the rs4648299 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs4648299 variant in the SNAI1 gene?
rs4648299 is a single nucleotide polymorphism (SNP) located in the SNAI1 (Snail Family Transcriptional Repressor 1) gene, which is involved in epithelial-mesenchymal transition / fibrosis. SNAI1 encodes the Snail transcription factor that drives epithelial-mesenchymal transition (EMT) by repressing E-cadherin and inducing mesenchymal markers.
How may the rs4648299 variant relate to Long COVID or ME/CFS?
SNAI1-driven EMT is a key mechanism of post-injury fibrosis; SARS-CoV-2 infection induces EMT in lung epithelial cells, with SNAI1 variants potentially affecting the degree of fibrotic EMT in Long COVID.
Can a consumer DNA test detect the rs4648299 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4648299 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SNAI1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33141942
- [2]Nature Genetics
- [3]Cell