rs363050
Variant in the SNAP25 gene (Synaptosomal-Associated Protein 25)
rs363050 is a single nucleotide polymorphism (SNP) in the SNAP25 gene, involved in vesicle fusion and neurotransmitter release. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs363050 variant?
rs363050 is a SNP (single nucleotide polymorphism) in the SNAP25 (Synaptosomal-Associated Protein 25) gene. It belongs to the Neuroplasticity category and is part of the Neurological & Cognitive Function biological cluster. SNAP25 is a SNARE complex protein essential for synaptic vesicle exocytosis and neurotransmitter release at synapses.
Biological role and pathway
This variant sits within the SNAP25 gene, which is involved in the vesicle fusion and neurotransmitter release pathway. Genes within the Neurological & Cognitive Function cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs363050 and Long COVID / ME-CFS research
SNAP25 variants affecting synaptic vesicle release may impair neurotransmission and contribute to neurological symptoms in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SNAP25
rs363050 is one of 2 known variants in the SNAP25 gene. To understand the full biological context of this variant, explore the parent gene page.
View SNAP25 gene page →Conditions studied in relation to rs363050
Research into SNAP25 variants including rs363050 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SNAP25 and the rs363050 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SNAP25 gene
The following variants in SNAP25 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs363050 variant in the SNAP25 gene?
rs363050 is a single nucleotide polymorphism (SNP) located in the SNAP25 (Synaptosomal-Associated Protein 25) gene, which is involved in vesicle fusion and neurotransmitter release. SNAP25 is a SNARE complex protein essential for synaptic vesicle exocytosis and neurotransmitter release at synapses.
How may the rs363050 variant relate to Long COVID or ME/CFS?
SNAP25 variants affecting synaptic vesicle release may impair neurotransmission and contribute to neurological symptoms in Long COVID.
Can a consumer DNA test detect the rs363050 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs363050 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SNAP25 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]Journal of Clinical Investigation