rs2239751
Variant in the SOCS1 gene (Suppressor Of Cytokine Signaling 1)
rs2239751 is a single nucleotide polymorphism (SNP) in the SOCS1 gene, involved in JAK-STAT regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2239751 variant?
rs2239751 is a SNP (single nucleotide polymorphism) in the SOCS1 (Suppressor Of Cytokine Signaling 1) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. SOCS1 is a feedback inhibitor of JAK-STAT signaling induced by cytokines and interferons. It targets JAK1 and JAK2 for degradation and acts as an E3 ligase substrate adaptor to suppress cytokine signaling.
Biological role and pathway
This variant sits within the SOCS1 gene, which is involved in the JAK-STAT regulation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2239751 and Long COVID / ME-CFS research
SOCS1 controls the duration of interferon and cytokine signaling. SOCS1 hypermethylation silences the gene in some contexts, allowing unchecked JAK-STAT activation. Variants or epigenetic dysregulation of SOCS1 may perpetuate the cytokine storm signature in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SOCS1
rs2239751 is one of 2 known variants in the SOCS1 gene. To understand the full biological context of this variant, explore the parent gene page.
View SOCS1 gene page →Conditions studied in relation to rs2239751
Research into SOCS1 variants including rs2239751 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SOCS1 and the rs2239751 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SOCS1 gene
The following variants in SOCS1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2239751 variant in the SOCS1 gene?
rs2239751 is a single nucleotide polymorphism (SNP) located in the SOCS1 (Suppressor Of Cytokine Signaling 1) gene, which is involved in JAK-STAT regulation. SOCS1 is a feedback inhibitor of JAK-STAT signaling induced by cytokines and interferons. It targets JAK1 and JAK2 for degradation and acts as an E3 ligase substrate adaptor to suppress cytokine signaling.
How may the rs2239751 variant relate to Long COVID or ME/CFS?
SOCS1 controls the duration of interferon and cytokine signaling. SOCS1 hypermethylation silences the gene in some contexts, allowing unchecked JAK-STAT activation. Variants or epigenetic dysregulation of SOCS1 may perpetuate the cytokine storm signature in Long COVID.
Can a consumer DNA test detect the rs2239751 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2239751 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SOCS1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 28738904
- [2]Nature Reviews Immunology
- [3]Journal of Immunology