rs9892622
Variant in the SOCS3 gene (Suppressor Of Cytokine Signaling 3)
rs9892622 is a single nucleotide polymorphism (SNP) in the SOCS3 gene, involved in JAK-STAT regulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs9892622 variant?
rs9892622 is a SNP (single nucleotide polymorphism) in the SOCS3 (Suppressor Of Cytokine Signaling 3) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. SOCS3 is a major negative regulator of IL-6 family cytokine and leptin signaling, acting on JAK2 and TYK2. It controls immune cell differentiation and systemic metabolic responses to cytokines.
Biological role and pathway
This variant sits within the SOCS3 gene, which is involved in the JAK-STAT regulation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs9892622 and Long COVID / ME-CFS research
SOCS3 curtails prolonged IL-6/JAK2 signaling. Viral manipulation of SOCS3 expression has been documented for several viruses. Persistent SOCS3 suppression by COVID-19 cytokine stimulation may allow sustained JAK-STAT-driven inflammation in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SOCS3
rs9892622 is one of 3 known variants in the SOCS3 gene. To understand the full biological context of this variant, explore the parent gene page.
View SOCS3 gene page →Conditions studied in relation to rs9892622
Research into SOCS3 variants including rs9892622 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SOCS3 and the rs9892622 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SOCS3 gene
The following variants in SOCS3 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs9892622 variant in the SOCS3 gene?
rs9892622 is a single nucleotide polymorphism (SNP) located in the SOCS3 (Suppressor Of Cytokine Signaling 3) gene, which is involved in JAK-STAT regulation. SOCS3 is a major negative regulator of IL-6 family cytokine and leptin signaling, acting on JAK2 and TYK2. It controls immune cell differentiation and systemic metabolic responses to cytokines.
How may the rs9892622 variant relate to Long COVID or ME/CFS?
SOCS3 curtails prolonged IL-6/JAK2 signaling. Viral manipulation of SOCS3 expression has been documented for several viruses. Persistent SOCS3 suppression by COVID-19 cytokine stimulation may allow sustained JAK-STAT-driven inflammation in Long COVID.
Can a consumer DNA test detect the rs9892622 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs9892622 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for SOCS3 and its variants. This is not an exhaustive literature review.
- [1]PMID: 30013104
- [2]Nature Immunology
- [3]Cell Metabolism