rs4958487
Variant in the SPARC gene (Secreted Protein Acidic And Cysteine Rich (Osteonectin))
rs4958487 is a single nucleotide polymorphism (SNP) in the SPARC gene, involved in ECM remodeling / collagen assembly. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4958487 variant?
rs4958487 is a SNP (single nucleotide polymorphism) in the SPARC (Secreted Protein Acidic And Cysteine Rich (Osteonectin)) gene. It belongs to the Connective Tissue category and is part of the Coagulation & Microcirculation biological cluster. SPARC encodes osteonectin/SPARC, a matricellular protein that regulates collagen matrix assembly, angiogenesis, and cell adhesion.
Biological role and pathway
This variant sits within the SPARC gene, which is involved in the ECM remodeling / collagen assembly pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4958487 and Long COVID / ME-CFS research
SPARC modulates post-injury tissue remodeling and fibrosis; variants may affect the degree of fibrotic remodeling in COVID-19-injured tissues relevant to Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SPARC
rs4958487 is one of 1 known variant in the SPARC gene. To understand the full biological context of this variant, explore the parent gene page.
View SPARC gene page →Conditions studied in relation to rs4958487
Research into SPARC variants including rs4958487 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SPARC and the rs4958487 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs4958487 variant in the SPARC gene?
rs4958487 is a single nucleotide polymorphism (SNP) located in the SPARC (Secreted Protein Acidic And Cysteine Rich (Osteonectin)) gene, which is involved in ECM remodeling / collagen assembly. SPARC encodes osteonectin/SPARC, a matricellular protein that regulates collagen matrix assembly, angiogenesis, and cell adhesion.
How may the rs4958487 variant relate to Long COVID or ME/CFS?
SPARC modulates post-injury tissue remodeling and fibrosis; variants may affect the degree of fibrotic remodeling in COVID-19-injured tissues relevant to Long COVID.
Can a consumer DNA test detect the rs4958487 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4958487 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SPARC and its variants. This is not an exhaustive literature review.
- [1]PMID: 33141942
- [2]Nature Genetics
- [3]Matrix Biology