rs1057233

What is the rs1057233 variant?

rs1057233 is a SNP (single nucleotide polymorphism) in the SPI1 (SPI1 Proto-Oncogene (PU.1)) gene. It belongs to the Immune Signaling category and is part of the Immune System & Inflammation biological cluster. SPI1 encodes PU.1, a transcription factor essential for myeloid cell differentiation and B cell development.

Biological role and pathway

This variant sits within the SPI1 gene, which is involved in the myeloid and B cell differentiation pathway. Genes within the Immune System & Inflammation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: SPI1

rs1057233 is one of 1 known variant in the SPI1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs1057233

Research into SPI1 variants including rs1057233 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SPI1 and the rs1057233 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions