rs4697086

What is the rs4697086 variant?

rs4697086 is a SNP (single nucleotide polymorphism) in the SQSTM1 (Sequestosome 1 (p62)) gene. It belongs to the Autophagy category and is part of the Autophagy biological cluster. SQSTM1 encodes p62, a selective autophagy receptor that links ubiquitinated cargo to the autophagosome machinery and regulates NF-kB signaling.

Biological role and pathway

This variant sits within the SQSTM1 gene, which is involved in the selective autophagy pathway. Genes within the Autophagy cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: SQSTM1

rs4697086 is one of 1 known variant in the SQSTM1 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs4697086

Research into SQSTM1 variants including rs4697086 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SQSTM1 and the rs4697086 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions