rs7582694

What is the rs7582694 variant?

rs7582694 is a SNP (single nucleotide polymorphism) in the STAT4 (Signal Transducer and Activator of Transcription 4) gene. It belongs to the Immune Signaling category and is part of the JAK-STAT Pathway biological cluster. STAT4 mediates IL-12 and IFN-alpha signals to drive Th1 differentiation and natural killer cell activation.

Biological role and pathway

This variant sits within the STAT4 gene, which is involved in the IL-12 and IFN-alpha signaling pathway. Genes within the JAK-STAT Pathway cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: STAT4

rs7582694 is one of 2 known variants in the STAT4 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs7582694

Research into STAT4 variants including rs7582694 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include STAT4 and the rs7582694 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the STAT4 gene

The following variants in STAT4 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions