rs2305234

What is the rs2305234 variant?

rs2305234 is a SNP (single nucleotide polymorphism) in the SUCLA2 (Succinate-CoA Ligase ADP-Forming Subunit Beta) gene. It belongs to the Metabolic category and is part of the Mitochondrial Energy Production & PEM biological cluster. SUCLA2 encodes the beta subunit of succinyl-CoA synthetase (ADP-forming), which catalyzes the TCA cycle step from succinyl-CoA to succinate.

Biological role and pathway

This variant sits within the SUCLA2 gene, which is involved in the TCA cycle / mitochondrial nucleotide synthesis pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: SUCLA2

rs2305234 is one of 1 known variant in the SUCLA2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs2305234

Research into SUCLA2 variants including rs2305234 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SUCLA2 and the rs2305234 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions