rs9282861
Variant in the SULT1A1 gene (Sulfotransferase Family 1A Member 1)
rs9282861 is a single nucleotide polymorphism (SNP) in the SULT1A1 gene, involved in phenol sulfotransferase / drug and hormone sulfation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs9282861 variant?
rs9282861 is a SNP (single nucleotide polymorphism) in the SULT1A1 (Sulfotransferase Family 1A Member 1) gene. It belongs to the Pharmacogenomics category and is part of the Detox & Medication Sensitivity biological cluster. SULT1A1 encodes the major phenol sulfotransferase, which sulfates phenolic drugs, neurotransmitters, and steroid hormones.
Biological role and pathway
This variant sits within the SULT1A1 gene, which is involved in the phenol sulfotransferase / drug and hormone sulfation pathway. Genes within the Detox & Medication Sensitivity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs9282861 and Long COVID / ME-CFS research
SULT1A1 variants (R213H copy number) affect sulfation of drugs and catecholamines; altered catecholamine sulfation may affect sympathetic tone in Long COVID dysautonomia.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SULT1A1
rs9282861 is one of 2 known variants in the SULT1A1 gene. To understand the full biological context of this variant, explore the parent gene page.
View SULT1A1 gene page →Conditions studied in relation to rs9282861
Research into SULT1A1 variants including rs9282861 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SULT1A1 and the rs9282861 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SULT1A1 gene
The following variants in SULT1A1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs9282861 variant in the SULT1A1 gene?
rs9282861 is a single nucleotide polymorphism (SNP) located in the SULT1A1 (Sulfotransferase Family 1A Member 1) gene, which is involved in phenol sulfotransferase / drug and hormone sulfation. SULT1A1 encodes the major phenol sulfotransferase, which sulfates phenolic drugs, neurotransmitters, and steroid hormones.
How may the rs9282861 variant relate to Long COVID or ME/CFS?
SULT1A1 variants (R213H copy number) affect sulfation of drugs and catecholamines; altered catecholamine sulfation may affect sympathetic tone in Long COVID dysautonomia.
Can a consumer DNA test detect the rs9282861 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs9282861 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SULT1A1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]Drug Metabolism and Disposition