rs296366
Variant in the SULT2A1 gene (Sulfotransferase Family 2A Member 1 (DHEA Sulfotransferase))
rs296366 is a single nucleotide polymorphism (SNP) in the SULT2A1 gene, involved in DHEA sulfation / adrenal steroid metabolism. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs296366 variant?
rs296366 is a SNP (single nucleotide polymorphism) in the SULT2A1 (Sulfotransferase Family 2A Member 1 (DHEA Sulfotransferase)) gene. It belongs to the Pharmacogenomics category and is part of the Detox & Medication Sensitivity biological cluster. SULT2A1 encodes DHEA sulfotransferase, which converts DHEA to DHEA-S, the major circulating adrenal androgen.
Biological role and pathway
This variant sits within the SULT2A1 gene, which is involved in the DHEA sulfation / adrenal steroid metabolism pathway. Genes within the Detox & Medication Sensitivity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs296366 and Long COVID / ME-CFS research
DHEA-S levels are influenced by SULT2A1; low DHEA-S in Long COVID may reflect impaired adrenal function, with SULT2A1 variants affecting the DHEA sulfation capacity.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SULT2A1
rs296366 is one of 1 known variant in the SULT2A1 gene. To understand the full biological context of this variant, explore the parent gene page.
View SULT2A1 gene page →Conditions studied in relation to rs296366
Research into SULT2A1 variants including rs296366 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SULT2A1 and the rs296366 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Frequently asked questions
What is the rs296366 variant in the SULT2A1 gene?
rs296366 is a single nucleotide polymorphism (SNP) located in the SULT2A1 (Sulfotransferase Family 2A Member 1 (DHEA Sulfotransferase)) gene, which is involved in DHEA sulfation / adrenal steroid metabolism. SULT2A1 encodes DHEA sulfotransferase, which converts DHEA to DHEA-S, the major circulating adrenal androgen.
How may the rs296366 variant relate to Long COVID or ME/CFS?
DHEA-S levels are influenced by SULT2A1; low DHEA-S in Long COVID may reflect impaired adrenal function, with SULT2A1 variants affecting the DHEA sulfation capacity.
Can a consumer DNA test detect the rs296366 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs296366 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for SULT2A1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32296168
- [2]Nature Genetics
- [3]Journal of Clinical Endocrinology