rs37841
Variant in the SYK gene (Spleen Associated Tyrosine Kinase)
rs37841 is a single nucleotide polymorphism (SNP) in the SYK gene, involved in immune receptor signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs37841 variant?
rs37841 is a SNP (single nucleotide polymorphism) in the SYK (Spleen Associated Tyrosine Kinase) gene. It belongs to the Adaptive Immunity category and is part of the Adaptive Immunity biological cluster. Syk is a tyrosine kinase that transduces signals from B cell receptors, Fc receptors, integrin signaling, and C-type lectin receptors. It is a convergence point for multiple immune activation pathways.
Biological role and pathway
This variant sits within the SYK gene, which is involved in the immune receptor signaling pathway. Genes within the Adaptive Immunity cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs37841 and Long COVID / ME-CFS research
Syk mediates platelet activation through CLEC2 and FcγRIIA, relevant to Long COVID coagulopathy. Its role in both B cell activation and platelet function makes SYK variants potentially important for multiple Long COVID pathological mechanisms.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: SYK
rs37841 is one of 3 known variants in the SYK gene. To understand the full biological context of this variant, explore the parent gene page.
View SYK gene page →Conditions studied in relation to rs37841
Research into SYK variants including rs37841 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include SYK and the rs37841 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the SYK gene
The following variants in SYK are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs37841 variant in the SYK gene?
rs37841 is a single nucleotide polymorphism (SNP) located in the SYK (Spleen Associated Tyrosine Kinase) gene, which is involved in immune receptor signaling. Syk is a tyrosine kinase that transduces signals from B cell receptors, Fc receptors, integrin signaling, and C-type lectin receptors. It is a convergence point for multiple immune activation pathways.
How may the rs37841 variant relate to Long COVID or ME/CFS?
Syk mediates platelet activation through CLEC2 and FcγRIIA, relevant to Long COVID coagulopathy. Its role in both B cell activation and platelet function makes SYK variants potentially important for multiple Long COVID pathological mechanisms.
Can a consumer DNA test detect the rs37841 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs37841 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for SYK and its variants. This is not an exhaustive literature review.
- [1]PMID: 30374160
- [2]Nature Immunology
- [3]Blood