rs3735976

What is the rs3735976 variant?

rs3735976 is a SNP (single nucleotide polymorphism) in the TAGLN (Transgelin (SM22-Alpha)) gene. It belongs to the Connective Tissue category and is part of the Coagulation & Microcirculation biological cluster. TAGLN encodes SM22-alpha/transgelin, an actin-binding protein expressed in smooth muscle and myofibroblasts.

Biological role and pathway

This variant sits within the TAGLN gene, which is involved in the smooth muscle / myofibroblast differentiation pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: TAGLN

rs3735976 is one of 1 known variant in the TAGLN gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs3735976

Research into TAGLN variants including rs3735976 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TAGLN and the rs3735976 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions