rs1135216
Variant in the TAP1 gene (Transporter Associated with Antigen Processing 1)
rs1135216 is a single nucleotide polymorphism (SNP) in the TAP1 gene, involved in MHC class I peptide loading. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1135216 variant?
rs1135216 is a SNP (single nucleotide polymorphism) in the TAP1 (Transporter Associated with Antigen Processing 1) gene. It belongs to the Immune Presentation category and is part of the HLA & Immune Presentation biological cluster. TAP1 forms a heterodimer with TAP2 to transport peptides into the ER for loading onto MHC class I molecules.
Biological role and pathway
This variant sits within the TAP1 gene, which is involved in the MHC class I peptide loading pathway. Genes within the HLA & Immune Presentation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1135216 and Long COVID / ME-CFS research
TAP1 efficiency affects the repertoire of viral peptides presented to CD8+ T cells, influencing cytotoxic immune responses in COVID-19 and Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TAP1
rs1135216 is one of 2 known variants in the TAP1 gene. To understand the full biological context of this variant, explore the parent gene page.
View TAP1 gene page →Conditions studied in relation to rs1135216
Research into TAP1 variants including rs1135216 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TAP1 and the rs1135216 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TAP1 gene
The following variants in TAP1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1135216 variant in the TAP1 gene?
rs1135216 is a single nucleotide polymorphism (SNP) located in the TAP1 (Transporter Associated with Antigen Processing 1) gene, which is involved in MHC class I peptide loading. TAP1 forms a heterodimer with TAP2 to transport peptides into the ER for loading onto MHC class I molecules.
How may the rs1135216 variant relate to Long COVID or ME/CFS?
TAP1 efficiency affects the repertoire of viral peptides presented to CD8+ T cells, influencing cytotoxic immune responses in COVID-19 and Long COVID.
Can a consumer DNA test detect the rs1135216 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1135216 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for TAP1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33888513
- [2]Nature Genetics
- [3]Journal of Clinical Investigation