rs4523
Variant in the TBXA2R gene (Thromboxane A2 Receptor)
rs4523 is a single nucleotide polymorphism (SNP) in the TBXA2R gene, involved in platelet activation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs4523 variant?
rs4523 is a SNP (single nucleotide polymorphism) in the TBXA2R (Thromboxane A2 Receptor) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. TBXA2R mediates platelet aggregation, vasoconstriction, and bronchoconstriction in response to thromboxane A2 produced by COX enzymes. Variants affect aspirin antiplatelet efficacy and platelet responsiveness.
Biological role and pathway
This variant sits within the TBXA2R gene, which is involved in the platelet activation pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs4523 and Long COVID / ME-CFS research
TXA2-mediated platelet activation contributes to COVID-19-associated thrombosis. TBXA2R variants affecting platelet TXA2 responsiveness may influence the degree of platelet hyperactivation and microthrombi formation in Long COVID coagulopathy.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TBXA2R
rs4523 is one of 3 known variants in the TBXA2R gene. To understand the full biological context of this variant, explore the parent gene page.
View TBXA2R gene page →Conditions studied in relation to rs4523
Research into TBXA2R variants including rs4523 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TBXA2R and the rs4523 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TBXA2R gene
The following variants in TBXA2R are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs4523 variant in the TBXA2R gene?
rs4523 is a single nucleotide polymorphism (SNP) located in the TBXA2R (Thromboxane A2 Receptor) gene, which is involved in platelet activation. TBXA2R mediates platelet aggregation, vasoconstriction, and bronchoconstriction in response to thromboxane A2 produced by COX enzymes. Variants affect aspirin antiplatelet efficacy and platelet responsiveness.
How may the rs4523 variant relate to Long COVID or ME/CFS?
TXA2-mediated platelet activation contributes to COVID-19-associated thrombosis. TBXA2R variants affecting platelet TXA2 responsiveness may influence the degree of platelet hyperactivation and microthrombi formation in Long COVID coagulopathy.
Can a consumer DNA test detect the rs4523 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs4523 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for TBXA2R and its variants. This is not an exhaustive literature review.
- [1]PMID: 27568270
- [2]Arteriosclerosis Thrombosis and Vascular Biology
- [3]Journal of Thrombosis and Haemostasis