rs7903146
Variant in the TCF7L2 gene (Transcription Factor 7 Like 2)
rs7903146 is a single nucleotide polymorphism (SNP) in the TCF7L2 gene, involved in Wnt/beta-catenin / insulin secretion. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs7903146 variant?
rs7903146 is a SNP (single nucleotide polymorphism) in the TCF7L2 (Transcription Factor 7 Like 2) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. TCF7L2 encodes a transcription factor downstream of Wnt signaling; it is the strongest common genetic risk factor for type 2 diabetes.
Biological role and pathway
This variant sits within the TCF7L2 gene, which is involved in the Wnt/beta-catenin / insulin secretion pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs7903146 and Long COVID / ME-CFS research
TCF7L2 variants (rs7903146) strongly increase T2D risk; new-onset diabetes following COVID-19 infection is well-documented, and TCF7L2 variants may modulate susceptibility to post-COVID metabolic complications.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TCF7L2
rs7903146 is one of 2 known variants in the TCF7L2 gene. To understand the full biological context of this variant, explore the parent gene page.
View TCF7L2 gene page →Conditions studied in relation to rs7903146
Research into TCF7L2 variants including rs7903146 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TCF7L2 and the rs7903146 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TCF7L2 gene
The following variants in TCF7L2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs7903146 variant in the TCF7L2 gene?
rs7903146 is a single nucleotide polymorphism (SNP) located in the TCF7L2 (Transcription Factor 7 Like 2) gene, which is involved in Wnt/beta-catenin / insulin secretion. TCF7L2 encodes a transcription factor downstream of Wnt signaling; it is the strongest common genetic risk factor for type 2 diabetes.
How may the rs7903146 variant relate to Long COVID or ME/CFS?
TCF7L2 variants (rs7903146) strongly increase T2D risk; new-onset diabetes following COVID-19 infection is well-documented, and TCF7L2 variants may modulate susceptibility to post-COVID metabolic complications.
Can a consumer DNA test detect the rs7903146 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs7903146 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for TCF7L2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33153018
- [2]Nature Genetics
- [3]NEJM