rs9606756
Variant in the TCN2 gene (Transcobalamin 2)
rs9606756 is a single nucleotide polymorphism (SNP) in the TCN2 gene, involved in B12 cellular uptake and transport. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs9606756 variant?
rs9606756 is a SNP (single nucleotide polymorphism) in the TCN2 (Transcobalamin 2) gene. It belongs to the Metabolic category and is part of the Methylation & Neurotransmitters biological cluster. TCN2 encodes transcobalamin II (TC II), the plasma vitamin B12-binding protein responsible for delivering B12 to tissues via cellular receptor-mediated endocytosis.
Biological role and pathway
This variant sits within the TCN2 gene, which is involved in the B12 cellular uptake and transport pathway. Genes within the Methylation & Neurotransmitters cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs9606756 and Long COVID / ME-CFS research
TCN2 variants (especially rs1801198 Pro/Arg) affect B12 cellular delivery; reduced TC II function may impair methylation and contribute to neurological and fatigue symptoms in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TCN2
rs9606756 is one of 2 known variants in the TCN2 gene. To understand the full biological context of this variant, explore the parent gene page.
View TCN2 gene page →Conditions studied in relation to rs9606756
Research into TCN2 variants including rs9606756 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TCN2 and the rs9606756 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TCN2 gene
The following variants in TCN2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs9606756 variant in the TCN2 gene?
rs9606756 is a single nucleotide polymorphism (SNP) located in the TCN2 (Transcobalamin 2) gene, which is involved in B12 cellular uptake and transport. TCN2 encodes transcobalamin II (TC II), the plasma vitamin B12-binding protein responsible for delivering B12 to tissues via cellular receptor-mediated endocytosis.
How may the rs9606756 variant relate to Long COVID or ME/CFS?
TCN2 variants (especially rs1801198 Pro/Arg) affect B12 cellular delivery; reduced TC II function may impair methylation and contribute to neurological and fatigue symptoms in Long COVID.
Can a consumer DNA test detect the rs9606756 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs9606756 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for TCN2 and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]American Journal of Clinical Nutrition
- [3]European Journal of Clinical Nutrition