rs10936599
Variant in the TERC gene (Telomerase RNA Component)
rs10936599 is a single nucleotide polymorphism (SNP) in the TERC gene, involved in telomere maintenance. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs10936599 variant?
rs10936599 is a SNP (single nucleotide polymorphism) in the TERC (Telomerase RNA Component) gene. It belongs to the Genome Stability category and is part of the Oxidative Stress biological cluster. TERC encodes the RNA template component of telomerase, providing the template for telomere repeat synthesis.
Biological role and pathway
This variant sits within the TERC gene, which is involved in the telomere maintenance pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs10936599 and Long COVID / ME-CFS research
TERC variants may affect telomere length maintenance; short telomeres are associated with impaired immune function and increased susceptibility to severe COVID-19 and Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TERC
rs10936599 is one of 2 known variants in the TERC gene. To understand the full biological context of this variant, explore the parent gene page.
View TERC gene page →Conditions studied in relation to rs10936599
Research into TERC variants including rs10936599 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TERC and the rs10936599 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TERC gene
The following variants in TERC are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs10936599 variant in the TERC gene?
rs10936599 is a single nucleotide polymorphism (SNP) located in the TERC (Telomerase RNA Component) gene, which is involved in telomere maintenance. TERC encodes the RNA template component of telomerase, providing the template for telomere repeat synthesis.
How may the rs10936599 variant relate to Long COVID or ME/CFS?
TERC variants may affect telomere length maintenance; short telomeres are associated with impaired immune function and increased susceptibility to severe COVID-19 and Long COVID.
Can a consumer DNA test detect the rs10936599 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs10936599 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for TERC and its variants. This is not an exhaustive literature review.
- [1]PMID: 34088393
- [2]Nature Genetics
- [3]NEJM