rs2736100
Variant in the TERT gene (Telomerase Reverse Transcriptase)
rs2736100 is a single nucleotide polymorphism (SNP) in the TERT gene, involved in telomere maintenance. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs2736100 variant?
rs2736100 is a SNP (single nucleotide polymorphism) in the TERT (Telomerase Reverse Transcriptase) gene. It belongs to the Genome Stability category and is part of the Oxidative Stress biological cluster. TERT encodes the catalytic subunit of telomerase, which extends telomeres to prevent cellular senescence.
Biological role and pathway
This variant sits within the TERT gene, which is involved in the telomere maintenance pathway. Genes within the Oxidative Stress cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs2736100 and Long COVID / ME-CFS research
Telomere shortening is accelerated by oxidative stress and inflammation; TERT variants may affect immune cell replicative capacity and cellular aging in Long COVID.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TERT
rs2736100 is one of 3 known variants in the TERT gene. To understand the full biological context of this variant, explore the parent gene page.
View TERT gene page →Conditions studied in relation to rs2736100
Research into TERT variants including rs2736100 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TERT and the rs2736100 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TERT gene
The following variants in TERT are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs2736100 variant in the TERT gene?
rs2736100 is a single nucleotide polymorphism (SNP) located in the TERT (Telomerase Reverse Transcriptase) gene, which is involved in telomere maintenance. TERT encodes the catalytic subunit of telomerase, which extends telomeres to prevent cellular senescence.
How may the rs2736100 variant relate to Long COVID or ME/CFS?
Telomere shortening is accelerated by oxidative stress and inflammation; TERT variants may affect immune cell replicative capacity and cellular aging in Long COVID.
Can a consumer DNA test detect the rs2736100 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs2736100 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for TERT and its variants. This is not an exhaustive literature review.
- [1]PMID: 34088393
- [2]Nature Genetics
- [3]NEJM