rs1937
Variant in the TFAM gene (Transcription Factor A, Mitochondrial)
rs1937 is a single nucleotide polymorphism (SNP) in the TFAM gene, involved in mitochondrial gene expression. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1937 variant?
rs1937 is a SNP (single nucleotide polymorphism) in the TFAM (Transcription Factor A, Mitochondrial) gene. It belongs to the Mitochondrial category and is part of the Mitochondrial Energy Production & PEM biological cluster. TFAM is a key regulator of mitochondrial DNA replication, transcription, and maintenance of mitochondrial genome integrity.
Biological role and pathway
This variant sits within the TFAM gene, which is involved in the mitochondrial gene expression pathway. Genes within the Mitochondrial Energy Production & PEM cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1937 and Long COVID / ME-CFS research
TFAM variants may impair mitochondrial DNA expression and biogenesis, contributing to mitochondrial dysfunction in Long COVID fatigue.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TFAM
rs1937 is one of 1 known variant in the TFAM gene. To understand the full biological context of this variant, explore the parent gene page.
View TFAM gene page →Conditions studied in relation to rs1937
Research into TFAM variants including rs1937 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TFAM and the rs1937 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TFAM gene
The following variants in TFAM are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1937 variant in the TFAM gene?
rs1937 is a single nucleotide polymorphism (SNP) located in the TFAM (Transcription Factor A, Mitochondrial) gene, which is involved in mitochondrial gene expression. TFAM is a key regulator of mitochondrial DNA replication, transcription, and maintenance of mitochondrial genome integrity.
How may the rs1937 variant relate to Long COVID or ME/CFS?
TFAM variants may impair mitochondrial DNA expression and biogenesis, contributing to mitochondrial dysfunction in Long COVID fatigue.
Can a consumer DNA test detect the rs1937 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1937 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for TFAM and its variants. This is not an exhaustive literature review.
- [1]PMID: 32735956
- [2]Nature Genetics
- [3]Journal of Clinical Investigation