rs3817672

What is the rs3817672 variant?

rs3817672 is a SNP (single nucleotide polymorphism) in the TFRC (Transferrin Receptor) gene. It belongs to the Vitamin Metabolism category and is part of the Vitamin & Nutrient Metabolism biological cluster. TFRC encodes transferrin receptor 1 (CD71), the cell-surface receptor that internalizes iron-loaded transferrin.

Biological role and pathway

This variant sits within the TFRC gene, which is involved in the cellular iron uptake pathway. Genes within the Vitamin & Nutrient Metabolism cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: TFRC

rs3817672 is one of 1 known variant in the TFRC gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs3817672

Research into TFRC variants including rs3817672 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TFRC and the rs3817672 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions