rs180195
Variant in the TG gene (Thyroglobulin)
rs180195 is a single nucleotide polymorphism (SNP) in the TG gene, involved in thyroid hormone storage and synthesis. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs180195 variant?
rs180195 is a SNP (single nucleotide polymorphism) in the TG (Thyroglobulin) gene. It belongs to the Metabolic category and is part of the Metabolic Regulation biological cluster. TG encodes thyroglobulin, the large glycoprotein serving as the scaffold for thyroid hormone synthesis and storage in thyroid follicles.
Biological role and pathway
This variant sits within the TG gene, which is involved in the thyroid hormone storage and synthesis pathway. Genes within the Metabolic Regulation cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs180195 and Long COVID / ME-CFS research
Thyroglobulin is the main thyroid autoantigen; anti-Tg antibodies occur in COVID-19 and may reflect post-infectious thyroid autoimmunity contributing to Long COVID thyroid dysfunction.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TG
rs180195 is one of 2 known variants in the TG gene. To understand the full biological context of this variant, explore the parent gene page.
View TG gene page →Conditions studied in relation to rs180195
Research into TG variants including rs180195 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TG and the rs180195 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TG gene
The following variants in TG are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs180195 variant in the TG gene?
rs180195 is a single nucleotide polymorphism (SNP) located in the TG (Thyroglobulin) gene, which is involved in thyroid hormone storage and synthesis. TG encodes thyroglobulin, the large glycoprotein serving as the scaffold for thyroid hormone synthesis and storage in thyroid follicles.
How may the rs180195 variant relate to Long COVID or ME/CFS?
Thyroglobulin is the main thyroid autoantigen; anti-Tg antibodies occur in COVID-19 and may reflect post-infectious thyroid autoimmunity contributing to Long COVID thyroid dysfunction.
Can a consumer DNA test detect the rs180195 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs180195 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for TG and its variants. This is not an exhaustive literature review.
- [1]PMID: 33664986
- [2]Nature Genetics
- [3]JCEM