rs3773651

What is the rs3773651 variant?

rs3773651 is a SNP (single nucleotide polymorphism) in the TGFBR2 (Transforming Growth Factor Beta Receptor 2) gene. It belongs to the Signaling category and is part of the Coagulation & Microcirculation biological cluster. TGFBR2 encodes the type II TGF-beta receptor that initiates signaling by binding TGF-beta and activating TGFBR1.

Biological role and pathway

This variant sits within the TGFBR2 gene, which is involved in the TGF-beta receptor / fibrosis / immune regulation pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: TGFBR2

rs3773651 is one of 2 known variants in the TGFBR2 gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs3773651

Research into TGFBR2 variants including rs3773651 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TGFBR2 and the rs3773651 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Other variants in the TGFBR2 gene

The following variants in TGFBR2 are also studied in relation to chronic illness and may be analysed together for a more complete picture.

Frequently asked questions