rs10770141

What is the rs10770141 variant?

rs10770141 is a SNP (single nucleotide polymorphism) in the TH (Tyrosine Hydroxylase) gene. It belongs to the Neurotransmitter category and is part of the Autonomic Nervous System biological cluster. TH encodes tyrosine hydroxylase, the rate-limiting enzyme in the biosynthesis of dopamine, norepinephrine, and epinephrine.

Biological role and pathway

This variant sits within the TH gene, which is involved in the catecholamine biosynthesis pathway. Genes within the Autonomic Nervous System cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: TH

rs10770141 is one of 1 known variant in the TH gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs10770141

Research into TH variants including rs10770141 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TH and the rs10770141 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions