rs1042580
Variant in the THBD gene (Thrombomodulin)
rs1042580 is a single nucleotide polymorphism (SNP) in the THBD gene, involved in anticoagulation. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs1042580 variant?
rs1042580 is a SNP (single nucleotide polymorphism) in the THBD (Thrombomodulin) gene. It belongs to the Coagulation category and is part of the Coagulation & Vascular biological cluster. Thrombomodulin is an endothelial receptor that binds thrombin and converts it from a procoagulant to an anticoagulant enzyme that activates protein C. It is a critical regulator of the thrombin-protein C anticoagulant pathway.
Biological role and pathway
This variant sits within the THBD gene, which is involved in the anticoagulation pathway. Genes within the Coagulation & Vascular cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs1042580 and Long COVID / ME-CFS research
Thrombomodulin expression is reduced in COVID-19 endothelial injury, impairing protein C activation and enabling coagulation. THBD variants affecting thrombomodulin function may contribute to COVID-19 coagulopathy that persists as microthrombi in Long COVID vascular disease.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: THBD
rs1042580 is one of 3 known variants in the THBD gene. To understand the full biological context of this variant, explore the parent gene page.
View THBD gene page →Conditions studied in relation to rs1042580
Research into THBD variants including rs1042580 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include THBD and the rs1042580 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the THBD gene
The following variants in THBD are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs1042580 variant in the THBD gene?
rs1042580 is a single nucleotide polymorphism (SNP) located in the THBD (Thrombomodulin) gene, which is involved in anticoagulation. Thrombomodulin is an endothelial receptor that binds thrombin and converts it from a procoagulant to an anticoagulant enzyme that activates protein C. It is a critical regulator of the thrombin-protein C anticoagulant pathway.
How may the rs1042580 variant relate to Long COVID or ME/CFS?
Thrombomodulin expression is reduced in COVID-19 endothelial injury, impairing protein C activation and enabling coagulation. THBD variants affecting thrombomodulin function may contribute to COVID-19 coagulopathy that persists as microthrombi in Long COVID vascular disease.
Can a consumer DNA test detect the rs1042580 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs1042580 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
Get Your Personalised DNA ReportInformational and educational only · Not a diagnostic tool · GDPR compliant
References
The following publications were used in compiling the research context for THBD and its variants. This is not an exhaustive literature review.
- [1]PMID: 32678530
- [2]Blood
- [3]Nature Medicine