rs5743836
Variant in the TICAM1 gene (TIR Domain Containing Adaptor Molecule 1 (TRIF))
rs5743836 is a single nucleotide polymorphism (SNP) in the TICAM1 gene, involved in TLR3/TLR4 adaptor signaling. Variants at this position have been studied in relation to immune function, metabolism, and chronic illness.
This page is for educational and informational purposes only. Not a diagnostic tool. Always consult a qualified healthcare provider.
What is the rs5743836 variant?
rs5743836 is a SNP (single nucleotide polymorphism) in the TICAM1 (TIR Domain Containing Adaptor Molecule 1 (TRIF)) gene. It belongs to the Innate Immunity category and is part of the Innate Immunity & Pattern Recognition biological cluster. TICAM1 encodes TRIF, the adaptor for MyD88-independent TLR3 and TLR4 signaling pathways that activate interferon regulatory factors.
Biological role and pathway
This variant sits within the TICAM1 gene, which is involved in the TLR3/TLR4 adaptor signaling pathway. Genes within the Innate Immunity & Pattern Recognition cluster work together to maintain balanced function across interconnected biological systems.
Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.
rs5743836 and Long COVID / ME-CFS research
TICAM1/TRIF-mediated interferon induction downstream of TLR3 is a key antiviral mechanism; variants may affect initial viral sensing in COVID-19.
This information is based on published research and does not constitute medical advice. See references below.
Parent gene: TICAM1
rs5743836 is one of 3 known variants in the TICAM1 gene. To understand the full biological context of this variant, explore the parent gene page.
View TICAM1 gene page →Conditions studied in relation to rs5743836
Research into TICAM1 variants including rs5743836 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.
Genetic insights from DNA data
Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TICAM1 and the rs5743836 variant.
The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.
Other variants in the TICAM1 gene
The following variants in TICAM1 are also studied in relation to chronic illness and may be analysed together for a more complete picture.
Frequently asked questions
What is the rs5743836 variant in the TICAM1 gene?
rs5743836 is a single nucleotide polymorphism (SNP) located in the TICAM1 (TIR Domain Containing Adaptor Molecule 1 (TRIF)) gene, which is involved in TLR3/TLR4 adaptor signaling. TICAM1 encodes TRIF, the adaptor for MyD88-independent TLR3 and TLR4 signaling pathways that activate interferon regulatory factors.
How may the rs5743836 variant relate to Long COVID or ME/CFS?
TICAM1/TRIF-mediated interferon induction downstream of TLR3 is a key antiviral mechanism; variants may affect initial viral sensing in COVID-19.
Can a consumer DNA test detect the rs5743836 variant?
Many consumer DNA tests such as 23andMe, AncestryDNA, and MyHeritage genotype common SNPs. ChronicDNA analyses your raw DNA file and reports on variants studied in relation to chronic illness, immune function, and metabolism. This is not a diagnostic service — results are informational and educational only.
Find out if you carry the rs5743836 variant
Upload your DNA data from 23andMe, AncestryDNA, or MyHeritage and receive a personalised report covering >80 genes relevant to Long COVID and ME/CFS.
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References
The following publications were used in compiling the research context for TICAM1 and its variants. This is not an exhaustive literature review.
- [1]PMID: 32972995
- [2]Nature Genetics
- [3]Journal of Clinical Investigation