rs639225

What is the rs639225 variant?

rs639225 is a SNP (single nucleotide polymorphism) in the TEK (TEK Receptor Tyrosine Kinase (TIE2)) gene. It belongs to the Vascular category and is part of the Coagulation & Microcirculation biological cluster. TEK encodes TIE2, the receptor for angiopoietins 1 and 2, which regulates vascular permeability and endothelial stability.

Biological role and pathway

This variant sits within the TEK gene, which is involved in the angiopoietin / vascular stability signaling pathway. Genes within the Coagulation & Microcirculation cluster work together to maintain balanced function across interconnected biological systems.

Variants in genes within this pathway may influence an individual's predisposition to altered function — particularly under conditions of physiological stress such as viral infection or prolonged illness.

Parent gene: TEK

rs639225 is one of 1 known variant in the TEK gene. To understand the full biological context of this variant, explore the parent gene page.

Conditions studied in relation to rs639225

Research into TEK variants including rs639225 has explored associations with the following conditions. These are areas of scientific investigation and do not imply causation.

Genetic insights from DNA data

Consumer DNA files from 23andMe, AncestryDNA, and MyHeritage contain raw SNP data. When you upload your file to ChronicDNA, the analysis engine checks your genotype against a curated panel of 80+ genes selected for their relevance to Long COVID, ME/CFS, and connected biological pathways - some of which may include TEK and the rs639225 variant.

The report is educational - it explains which variants you carry, what the research says about them, and how they fit into the biological pathways most relevant to chronic illness. Results are presented in plain English with appropriate scientific context, no medical jargon, no scare tactics. All results should be discussed with a qualified healthcare provider.

Frequently asked questions